Mithrl
San Francisco, California
About Mithrl We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building the world's first commercially available AI Co-Scientist. It is a discovery engine that transforms messy biological data into insights in minutes. Scientists ask questions in natural language, and Mithrl responds with real analysis, novel targets, hypotheses, and patent-ready reports. Our traction speaks for itself: 12X year-over-year revenue growth Trusted by leading biotechs and big pharma across three continents Driving real breakthroughs from target discovery to patient outcomes. The Role We are hiring a Senior Full Stack Engineer to help build, scale, and evolve the core Mithrl product. This is a highly product-oriented engineering role with deep ownership across frontend, backend, and system design. You will work closely with product, design, ML, and scientific teams to turn complex scientific workflows into intuitive, high-performance software used daily by world-class researchers. As a senior engineer, you will be responsible not just for execution, but for technical direction, architectural decisions, and setting engineering standards . You will own features end-to-end, from initial concept through production, iteration, and scale. This role requires strong full-stack engineering fundamentals, a bias toward shipping, and the ability to operate comfortably in ambiguous, fast-moving environments. If you enjoy building real products used by sophisticated users, thinking deeply about system design and user experience, and taking ownership of critical parts of a fast-growing platform, this role is an ideal match. What You Will Do Design, build, and maintain core Mithrl product features across frontend and backend Own end-to-end feature development, from product requirements to production deployment and iteration Build intuitive user interfaces that abstract complex scientific and data workflows Develop scalable backend services, APIs, and data pipelines that power the Mithrl platform Collaborate closely with product, design, ML, and scientific teams to translate user needs into technical solutions Make architectural decisions that balance speed, scalability, reliability, and developer velocity Improve system performance, reliability, and observability as usage and data volumes grow Write clean, maintainable, and well-tested code that sets a high bar for quality Mentor junior engineers and contribute to raising the overall engineering bar Participate in technical planning, code reviews, and ongoing platform evolution What You Bring Required Qualifications 7+ years of professional software engineering experience Strong full-stack engineering experience with Python and React in production environments Proficiency in Django for building backend APIs, services, and data-intensive systems Strong experience building modern frontend applications using React Experience designing and working with GraphQL APIs, including schema design, performance considerations, and client-server data modeling Experience designing and working with scalable systems, databases, and data-intensive applications Strong understanding of system design, software architecture, and engineering best practices Experience shipping and owning production systems used by real customers Ability to work effectively in fast-paced, ambiguous environments Strong problem solving skills and a product-oriented mindset Excellent communication skills and ability to collaborate cross-functionally Nice to Have Experience building products for technical or scientific users Familiarity with data-heavy, analytics, or ML-enabled platforms Experience with cloud infrastructure such as AWS, GCP, or Azure Experience mentoring or leading other engineers Exposure to biotech, life sciences, or R&D workflows What You Will Love At Mithrl High ownership and impact: You will own meaningful parts of a category-defining product used by leading pharma and biotech organizations. Your work will directly shape how scientists interact with AI and data on a daily basis Team: Join a tight-knit, talent-dense team of engineers, scientists, and builders Culture: We value consistency, clarity, and hard work. We solve hard problems through focused daily execution Speed: We ship fast (2x/week) and improve continuously based on real user feedback Location: Beautiful SF office with a high-energy, in-person culture Benefits: Comprehensive PPO health coverage through Anthem (medical, dental, and vision) + 401(k) with top-tier plans We encourage you to apply even if you do not believe you meet every single qualification. Not all strong candidates will meet every single qualification as listed. Research shows that people who identify as being from underrepresented groups are more prone to experiencing imposter syndrome and doubting the strength of their candidacy, so we urge you not to exclude yourself prematurely and to submit an application if you're interested in this work. We think AI systems like the ones we're building have enormous social and ethical implications. We think this makes representation even more important, and we strive to include a range of diverse perspectives on our team. Compensation Range: $175K - $220K
About Mithrl We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building the world's first commercially available AI Co-Scientist. It is a discovery engine that transforms messy biological data into insights in minutes. Scientists ask questions in natural language, and Mithrl responds with real analysis, novel targets, hypotheses, and patent-ready reports. Our traction speaks for itself: 12X year-over-year revenue growth Trusted by leading biotechs and big pharma across three continents Driving real breakthroughs from target discovery to patient outcomes. The Role We are hiring a Senior Full Stack Engineer to help build, scale, and evolve the core Mithrl product. This is a highly product-oriented engineering role with deep ownership across frontend, backend, and system design. You will work closely with product, design, ML, and scientific teams to turn complex scientific workflows into intuitive, high-performance software used daily by world-class researchers. As a senior engineer, you will be responsible not just for execution, but for technical direction, architectural decisions, and setting engineering standards . You will own features end-to-end, from initial concept through production, iteration, and scale. This role requires strong full-stack engineering fundamentals, a bias toward shipping, and the ability to operate comfortably in ambiguous, fast-moving environments. If you enjoy building real products used by sophisticated users, thinking deeply about system design and user experience, and taking ownership of critical parts of a fast-growing platform, this role is an ideal match. What You Will Do Design, build, and maintain core Mithrl product features across frontend and backend Own end-to-end feature development, from product requirements to production deployment and iteration Build intuitive user interfaces that abstract complex scientific and data workflows Develop scalable backend services, APIs, and data pipelines that power the Mithrl platform Collaborate closely with product, design, ML, and scientific teams to translate user needs into technical solutions Make architectural decisions that balance speed, scalability, reliability, and developer velocity Improve system performance, reliability, and observability as usage and data volumes grow Write clean, maintainable, and well-tested code that sets a high bar for quality Mentor junior engineers and contribute to raising the overall engineering bar Participate in technical planning, code reviews, and ongoing platform evolution What You Bring Required Qualifications 7+ years of professional software engineering experience Strong full-stack engineering experience with Python and React in production environments Proficiency in Django for building backend APIs, services, and data-intensive systems Strong experience building modern frontend applications using React Experience designing and working with GraphQL APIs, including schema design, performance considerations, and client-server data modeling Experience designing and working with scalable systems, databases, and data-intensive applications Strong understanding of system design, software architecture, and engineering best practices Experience shipping and owning production systems used by real customers Ability to work effectively in fast-paced, ambiguous environments Strong problem solving skills and a product-oriented mindset Excellent communication skills and ability to collaborate cross-functionally Nice to Have Experience building products for technical or scientific users Familiarity with data-heavy, analytics, or ML-enabled platforms Experience with cloud infrastructure such as AWS, GCP, or Azure Experience mentoring or leading other engineers Exposure to biotech, life sciences, or R&D workflows What You Will Love At Mithrl High ownership and impact: You will own meaningful parts of a category-defining product used by leading pharma and biotech organizations. Your work will directly shape how scientists interact with AI and data on a daily basis Team: Join a tight-knit, talent-dense team of engineers, scientists, and builders Culture: We value consistency, clarity, and hard work. We solve hard problems through focused daily execution Speed: We ship fast (2x/week) and improve continuously based on real user feedback Location: Beautiful SF office with a high-energy, in-person culture Benefits: Comprehensive PPO health coverage through Anthem (medical, dental, and vision) + 401(k) with top-tier plans We encourage you to apply even if you do not believe you meet every single qualification. Not all strong candidates will meet every single qualification as listed. Research shows that people who identify as being from underrepresented groups are more prone to experiencing imposter syndrome and doubting the strength of their candidacy, so we urge you not to exclude yourself prematurely and to submit an application if you're interested in this work. We think AI systems like the ones we're building have enormous social and ethical implications. We think this makes representation even more important, and we strive to include a range of diverse perspectives on our team. Compensation Range: $175K - $220K
Mithrl
San Francisco, California
About Mithrl We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building the world's first commercially available AI Co-Scientist. It is a discovery engine that transforms messy biological data into insights in minutes. Scientists ask questions in natural language, and Mithrl responds with real analysis, novel targets, hypotheses, and patent-ready reports. Our traction speaks for itself 12X year-over-year revenue growth Trusted by leading biotechs and big pharma across three continents Driving real breakthroughs from target discovery to patient outcomes. About The Role We are hiring an ML Engineer, Analysis and Simulation to build the core analytical and reasoning layer behind the Mithrl AI Co-Scientist. Your work will define how the AI interprets biological datasets, generates scientific conclusions, and orchestrates downstream simulation tools for drug discovery. You will develop the reusable analysis modules that Mithrl runs for every dataset, and you will design multi step agentic workflows that combine statistical analysis, biological reasoning, and computational modeling. You will also integrate and experiment with simulation tools for small molecule discovery, such as ADMET prediction, docking scoring, Boltzmann generators and related computational chemistry engines. This is the role that makes the AI Co-Scientist smart. If you have a strong background in ML, computational biology, and scientific analysis workflows, and you want to shape how AI reasons about biological systems, this is an exceptional opportunity. What You Will Do Build AI driven analysis agents that perform biological reasoning across a wide range of datasets Develop the standard analysis suite for each dataset, including modules for differential expression, pathway analysis, feature importance, clustering, scoring, enrichment, and mechanism-of-action interpretation Build multi step workflows that combine ML models, statistical logic, and biological knowledge to produce high confidence insights Design and implement agentic reasoning strategies that allow Mithrl to run dozens analyses per dataset and synthesize the outputs into a coherent scientific narrative Integrate simulation and modeling tools for small molecule drug discovery, including ADMET prediction, docking scoring, generative chemistry tools, structure based modeling, and related computational frameworks Collaborate with the data engineering, bioinformatics, and curation teams to ensure analysis modules operate on clean and consistent data Validate results, benchmark pipelines, and ensure scientific accuracy and reproducibility of all analyses Contribute to the long term architecture for how the AI Co-Scientist performs reasoning, hypothesis testing, and simulation What You Bring Required Qualifications Strong experience in machine learning, computational biology, or a related scientific ML field Experience developing analysis modules for biological or scientific datasets Familiarity with common techniques in target discovery, gene expression analysis, pathway inference, clustering, or statistical modeling Hands on experience with computational chemistry or simulation tools, such as ADMET models, docking, binding prediction, or molecular generative models Proficiency in Python and scientific computing libraries Experience designing multi step reasoning or workflow based ML pipelines Ability to translate messy scientific questions into structured ML or analytical workflows Strong communication skills and comfort collaborating with cross functional scientific and engineering teams Nice to Have Experience with LLM powered scientific agents or multi agent architectures Familiarity with phenotype based discovery, multi modal integration, or systems biology Background in computational chemistry or structure based drug discovery Experience with biological ontologies, curated knowledge graphs, or pathway databases Prior experience in a tech bio company, biotech R&D group, or scientific platform team What You Will Love At Mithrl High ownership: You will define how the AI Co-Scientist thinks and reasons about biology Impact: You will work at the intersection of ML, biology, and simulation, with direct impact on real discovery programs Team: Join a tight knit, talent dense team of engineers, scientists, and builders Culture: We value consistency, clarity, and hard work. We solve hard problems through focused daily execution Speed: We ship fast (2x/week) and improve continuously based on real user feedback Location: Beautiful SF office with a high energy, in person culture Benefits: Comprehensive PPO health coverage through Anthem (medical, dental, and vision) + 401(k) with top tier plans We encourage you to apply even if you do not believe you meet every single qualification. Not all strong candidates will meet every single qualification as listed. Research shows that people who identify as being from underrepresented groups are more prone to experiencing imposter syndrome and doubting the strength of their candid, so we urge you not to exclude yourself prematurely and to submit an application if you're interested in this work. We think AI systems like the ones we're building have enormous social and ethical implications. We think this makes representation even more important, and we strive to include a range of diverse perspectives on our team. Compensation Range: $150K - $200K
About Mithrl We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building the world's first commercially available AI Co-Scientist. It is a discovery engine that transforms messy biological data into insights in minutes. Scientists ask questions in natural language, and Mithrl responds with real analysis, novel targets, hypotheses, and patent-ready reports. Our traction speaks for itself 12X year-over-year revenue growth Trusted by leading biotechs and big pharma across three continents Driving real breakthroughs from target discovery to patient outcomes. About The Role We are hiring an ML Engineer, Analysis and Simulation to build the core analytical and reasoning layer behind the Mithrl AI Co-Scientist. Your work will define how the AI interprets biological datasets, generates scientific conclusions, and orchestrates downstream simulation tools for drug discovery. You will develop the reusable analysis modules that Mithrl runs for every dataset, and you will design multi step agentic workflows that combine statistical analysis, biological reasoning, and computational modeling. You will also integrate and experiment with simulation tools for small molecule discovery, such as ADMET prediction, docking scoring, Boltzmann generators and related computational chemistry engines. This is the role that makes the AI Co-Scientist smart. If you have a strong background in ML, computational biology, and scientific analysis workflows, and you want to shape how AI reasons about biological systems, this is an exceptional opportunity. What You Will Do Build AI driven analysis agents that perform biological reasoning across a wide range of datasets Develop the standard analysis suite for each dataset, including modules for differential expression, pathway analysis, feature importance, clustering, scoring, enrichment, and mechanism-of-action interpretation Build multi step workflows that combine ML models, statistical logic, and biological knowledge to produce high confidence insights Design and implement agentic reasoning strategies that allow Mithrl to run dozens analyses per dataset and synthesize the outputs into a coherent scientific narrative Integrate simulation and modeling tools for small molecule drug discovery, including ADMET prediction, docking scoring, generative chemistry tools, structure based modeling, and related computational frameworks Collaborate with the data engineering, bioinformatics, and curation teams to ensure analysis modules operate on clean and consistent data Validate results, benchmark pipelines, and ensure scientific accuracy and reproducibility of all analyses Contribute to the long term architecture for how the AI Co-Scientist performs reasoning, hypothesis testing, and simulation What You Bring Required Qualifications Strong experience in machine learning, computational biology, or a related scientific ML field Experience developing analysis modules for biological or scientific datasets Familiarity with common techniques in target discovery, gene expression analysis, pathway inference, clustering, or statistical modeling Hands on experience with computational chemistry or simulation tools, such as ADMET models, docking, binding prediction, or molecular generative models Proficiency in Python and scientific computing libraries Experience designing multi step reasoning or workflow based ML pipelines Ability to translate messy scientific questions into structured ML or analytical workflows Strong communication skills and comfort collaborating with cross functional scientific and engineering teams Nice to Have Experience with LLM powered scientific agents or multi agent architectures Familiarity with phenotype based discovery, multi modal integration, or systems biology Background in computational chemistry or structure based drug discovery Experience with biological ontologies, curated knowledge graphs, or pathway databases Prior experience in a tech bio company, biotech R&D group, or scientific platform team What You Will Love At Mithrl High ownership: You will define how the AI Co-Scientist thinks and reasons about biology Impact: You will work at the intersection of ML, biology, and simulation, with direct impact on real discovery programs Team: Join a tight knit, talent dense team of engineers, scientists, and builders Culture: We value consistency, clarity, and hard work. We solve hard problems through focused daily execution Speed: We ship fast (2x/week) and improve continuously based on real user feedback Location: Beautiful SF office with a high energy, in person culture Benefits: Comprehensive PPO health coverage through Anthem (medical, dental, and vision) + 401(k) with top tier plans We encourage you to apply even if you do not believe you meet every single qualification. Not all strong candidates will meet every single qualification as listed. Research shows that people who identify as being from underrepresented groups are more prone to experiencing imposter syndrome and doubting the strength of their candid, so we urge you not to exclude yourself prematurely and to submit an application if you're interested in this work. We think AI systems like the ones we're building have enormous social and ethical implications. We think this makes representation even more important, and we strive to include a range of diverse perspectives on our team. Compensation Range: $150K - $200K