9 jobs found

Lonza is seeking an IT Solution Architect to design and lead enterprise IT solutions that power cutting-edge biopharma development and manufacturing. In this role, you will translate complex business and scientific needs into secure, scalable architectures across applications, data, and infrastructure. You will partner with R&D, manufacturing, quality, and global IT teams to deliver compliant, GxP-ready solutions that support regulated operations. The position offers exposure to advanced technologies, cross-functional projects, and a culture focused on innovation, quality, and patient-centric outcomes. Responsibilities Design and architect IT solutions that support Lonza's biopharma development and manufacturing processes Translate business and scientific requirements into scalable, secure system architectures Lead end-to-end solution design across applications, data, and infrastructure domains Ensure solutions comply with Gx P and other regulatory and cybersecurity standards Collaborate with R&D, manufacturing, quality, and IT teams on global projects Evaluate and integrate cloud, data, and enterprise platforms to optimize operations Create architecture diagrams, technical specifications, and integration patterns Guide implementation teams and provide technical governance throughout projects Drive standardization, reuse, and lifecycle management of enterprise solutions Support continuous improvement and innovation in Lonza's digital ecosystem Required Skills Enterprise architecture design (applications, data, infrastructure) Cloud platforms (AWS, Azure, or GCP) Systems integration (APIs, ESB, microservices) Database and data architecture (SQL/No SQL, data modeling) Gx P and CSV compliance in regulated environments Cybersecurity and identity/access management Architecture frameworks (TOGAF or similar) Dev Ops and CI/CD concepts Documentation and modeling (UML, Archi Mate, Visio, or similar) Stakeholder management and technical leadership

Lonza is seeking an Automation & MES Delivery Lead to drive design, implementation, and lifecycle management of manufacturing execution and automation systems in a regulated biopharmaceutical environment. You will lead end-to-end delivery of MES/automation solutions for drug substance and drug product facilities, translating manufacturing and quality requirements into robust digital workflows. Responsibilities include solution architecture, vendor and system integration oversight, project delivery, validation support, and continuous improvement. You will partner with operations, QA, IT, and global engineering, ensuring GxP compliance, data integrity, and high system reliability in support of safe, efficient, and scalable biopharma production. Responsibilities Lead end-to-end delivery of MES and automation solutions for biopharma manufacturing sites Translate manufacturing, quality, and regulatory requirements into system designs and workflows Define solution architecture and oversee integration with ERP, LIMS, and control systems Coordinate vendors, internal IT, engineering, and operations for successful project execution Support computer system validation, testing, and documentation in line with Gx P and data integrity Monitor and improve system performance, reliability, and user experience Drive standardization and continuous improvement of MES/automation templates and processes Ensure compliance with global and local regulations, including 21 CFR Part 11 Provide subject matter expertise and training to end users and project teams Contribute to digitalization roadmap and technology selection for manufacturing IT/OT Required Skills Manufacturing Execution Systems (MES) Automation systems (PLC/SCADA/DCS) System integration and interfaces (ERP/LIMS/Delta V/SAP) Gx P and FDA/EMA regulations Computer system validation (CSV)21 CFR Part 11 and data integrity Requirements gathering and process mapping Project and delivery management Biopharmaceutical manufacturing processes Change management and continuous improvement

Lonza is seeking an IT Solution Architect to design and implement scalable, secure IT solutions that support biopharma development and manufacturing. In this role, you will translate scientific and business needs into robust architectures, integrating lab, manufacturing, and enterprise systems in a GxP-regulated environment. You will collaborate with global, cross-functional teams, ensure compliance and data integrity, and drive standardization and innovation across Lonza's digital landscape. This position offers exposure to advanced technologies, international projects, and a mission-driven culture focused on patient outcomes. Responsibilities Design and implement IT solutions supporting Lonza's biopharma manufacturing and development processes Translate business and scientific requirements into scalable, secure IT architectures Integrate laboratory, manufacturing, and enterprise systems ensuring data integrity and compliance Collaborate with cross-functional teams across global sites to deliver end-to-end solutions Ensure architectures meet regulatory, Gx P, security, and quality standards Evaluate and select appropriate technologies, platforms, and integration patterns Create technical documentation, diagrams, and standards for implemented solutions Lead solution design reviews and provide technical guidance to project teams Support lifecycle management, upgrades, and optimization of IT systems Contribute to continuous improvement and innovation in Lonza's digital landscape Required Skills Solution architecture Enterprise integration (APIs, ESB, middleware) Cloud platforms (AWS, Azure, or GCP) Gx P and CSV compliance Biotech/pharma manufacturing or lab systems (LIMS, MES, ERP) Information security and data integrity Requirements analysis and stakeholder management System design and technical documentation Database and data modeling Project delivery in regulated environments

Lonza is seeking an Automation & MES Delivery Lead to drive design, implementation, and lifecycle management of manufacturing execution and automation systems in a regulated biopharmaceutical environment. You will lead end-to-end delivery of MES/automation solutions for drug substance and drug product facilities, translating manufacturing and quality requirements into robust digital workflows. Responsibilities include solution architecture, vendor and system integration oversight, project delivery, validation support, and continuous improvement. You will partner with operations, QA, IT, and global engineering, ensuring GxP compliance, data integrity, and high system reliability in support of safe, efficient, and scalable biopharma production. Responsibilities Lead end-to-end delivery of MES and automation solutions for biopharma manufacturing sites Translate manufacturing, quality, and regulatory requirements into system designs and workflows Define solution architecture and oversee integration with ERP, LIMS, and control systems Coordinate vendors, internal IT, engineering, and operations for successful project execution Support computer system validation, testing, and documentation in line with Gx P and data integrity Monitor and improve system performance, reliability, and user experience Drive standardization and continuous improvement of MES/automation templates and processes Ensure compliance with global and local regulations, including 21 CFR Part 11 Provide subject matter expertise and training to end users and project teams Contribute to digitalization roadmap and technology selection for manufacturing IT/OT Required Skills Manufacturing Execution Systems (MES) Automation systems (PLC/SCADA/DCS) System integration and interfaces (ERP/LIMS/Delta V/SAP) Gx P and FDA/EMA regulations Computer system validation (CSV)21 CFR Part 11 and data integrity Requirements gathering and process mapping Project and delivery management Biopharmaceutical manufacturing processes Change management and continuous improvement

Job Description Date Posted: 2026-11-12 Country: United States of America Location: US-TX-MCKINNEY-513WD 2501 W University Dr WING D BLDG Position Role Type: Hybrid U.S. Citizen, U.S. Person, or Immigration Status Requirements: The ability to obtain and maintain a U.S. government issued security clearance is required. U.S. citizenship is required, as only U.S. citizens are eligible for a security clearance Security Clearance Type: DoD Clearance: Top Secret Security Clearance Status: Active and existing security clearance required after day 1 At RTX, the world largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world's most complex problems. With our three market leading businesses, world-class operations and investments in research and development, we offer capabilities and opportunity no one else can. Together, we push the boundaries of known science and find new ways to connect and protect our world. Raytheon brings the strength of more than 100 years of experience and renowned engineering expertise to meet the needs of today's mission and stay ahead of tomorrow's threat. We deliver solutions that help our nation and allies defend freedoms, and deter aggression, creating a safer, more secure world. Join us and help shape the future of aerospace and defense. Affordability Engineering at Raytheon focuses on delivering optimized solutions across the entire product lifecycle, integrating technical performance, design choices, manufacturing behavior, supplier inputs, sustainment considerations, and readiness metrics into a unified cost and throughput framework. As a Systems Engineer II - Affordability Theory of Constraint (TOC), you will play a key role in supporting the development and execution of discrete event simulation (DES) models to identify system constraints, characterize resource interactions, quantify throughput impacts, and assess cost and schedule sensitivities. Your work will enable program leadership to make informed, data-driven decisions that balance cost, performance, schedule, and mission needs. This is an onsite role based in McKinney, TX. What You Will Do Develop, execute, and maintain discrete event simulation models to analyze throughput, queueing behavior, cycle time, resource constraints, and system bottlenecks. Prepare model input datasets using validated engineering, operations, supplier, and sustainment data. Identify and characterize constraints across production lines, supply chain flows, and sustainment/repair loops. Analyze the impact of design decisions, yield variations, staffing assumptions, or supplier performance on system throughput and affordability. Conduct multi-scenario studies, sensitivity analyses, and parameter sweeps. Document model assumptions, boundaries, and data traceability to ensure credibility and repeatability. Support affordability assessments, including lifecycle cost modeling, business case analyses, and readiness/availability studies. Collaborate with Affordability Leads and cross-functional teams to align model outputs with program requirements. Update model inputs as new data becomes available to ensure accurate reflection of system behavior. Qualifications You Must Have Typically requires a degree in Science, Technology, Engineering or Mathematics (STEM) and a minimum of 2 years of prior relevant experience. Experience in Systems Engineering, operations research, Industrial Engineering, or related analytical disciplines. Experience working with structured datasets (Excel, CSV, databases) for data analysis and/or model input preparation. Experience building or using discrete event simulation tools (e.g., ExtendSim, Simio, Arena, or similar platforms). Qualifications We Prefer Experience presenting to internal stakeholders. Experience analyzing production and supply chain performance, including queueing behavior, yields, resource constraints, rework/repair flows, and operational risk drivers. Experience executing scenario analyses such as parameter sweeps, sensitivity studies, or Monte Carlo simulations, using structured data inputs (e.g., Excel, databases). Experience using data visualization and analytics tools (Python, Power BI, Tableau, JMP) to interpret simulation outputs and support lifecycle cost, affordability, or readiness assessments. Experience collaborating with cross-functional teams and supporting system-of-systems evaluations across manufacturing, supply chain, engineering, and program teams. What We Offer Our values drive our actions, behaviors, and performance with a vision for a safer, more connected world. At RTX we value: Safety, Trust, Respect, Accountability, Collaboration, and Innovation. Relocation Eligible - Relocation assistance is available. Learn More & Apply Now! Please consider the following role type definition as you apply for this role. Onsite: Employees who are working in Onsite roles will work primarily onsite. This includes all production and maintenance employees, as they are essential to the development of our products. This position requires a security clearance. DCSA Consolidated Adjudication Services (DCSA CAS), an agency of the Department of Defense, handles and adjudicates the security clearance process. More information about Security Clearances can be found on the US Department of State government website here: This position is an onsite role - McKinney, TX. We Are RTX As part of our commitment to maintaining a secure hiring process, candidates may be asked to attend select steps of the interview process in-person at one of our office locations, regardless of whether the role is designated as on-site, hybrid or remote. The salary range for this role is 68,900 USD - 131,100 USD. The salary range provided is a good faith estimate representative of all experience levels. RTX considers several factors when extending an offer, including but not limited to, the role, function and associated responsibilities, a candidate's work experience, location, education/training, and key skills. Hired applicants may be eligible for benefits, including but not limited to, medical, dental, vision, life insurance, short-term disability, long-term disability, 401(k) match, flexible spending accounts, flexible work schedules, employee assistance program, Employee Scholar Program, parental leave, paid time off, and holidays. Specific benefits are dependent upon the specific business unit as well as whether or not the position is covered by a collective-bargaining agreement. Hired applicants may be eligible for annual short-term and/or long-term incentive compensation programs depending on the level of the position and whether or not it is covered by a collective-bargaining agreement. Payments under these annual programs are not guaranteed and are dependent upon a variety of factors including, but not limited to, individual performance, business unit performance, and/or the company's performance. This role is a U.S.-based role. If the successful candidate resides in a U.S. territory, the appropriate pay structure and benefits will apply. RTX anticipates the application window closing approximately 40 days from the date the notice was posted. However, factors such as candidate flow and business necessity may require RTX to shorten or extend the application window. RTX is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or veteran status, or any other applicable state or federal protected class. RTX provides affirmative action in employment for qualified Individuals with a Disability and Protected Veterans in compliance with Section 503 of the Rehabilitation Act and the Vietnam Era Veterans' Readjustment Assistance Act. Privacy Policy and Terms: Click on this link to read the Policy and Terms